Christian attempts to cope in the aftermath of Gina’s death; A young couple seeks plastic surgery to hide a terrible secret. Colleen has foot bone reconstruction, and feels threatened when another talent agency shows an interest in Sean’s acting career.

House and the team treat a woman (Janel Moloney) who suffers from a sudden paralysis of the hands that causes an injury to her daughter while she’s spotting her at an indoor rock-climbing wall. As House probes the woman and her injured daughter for any leads as to what might be causing her condition, House is convinced that the woman is withholding information. When the woman’s daughter reveals some very descriptive details about her mother’s personal life, House isn’t so sure the woman hides anything about herself from the people around her, especially her daughter. As the team runs tests to find out what caused her paralysis, the woman loses her eyesight and her system begins to shut down, and House and the team are baffled as to whether it is the woman herself, or her own physiology that is lying to them.

Bette’s jealousy over Tina’s new girlfriend is the probable cause of a surprising romantic moment. Meanwhile, Jenny takes over casting for ‘Lez Girls’ and is courted for playing the lead in her movie by the latest Bond girl. Also, the gang attends the grand opening of SheBar which is competing with The Planet.